SCN8A transcripts, the density of which is maintained by the composition of white-matter 74, may be altered by interaction with SCN4B isoforms and in turn collectively affect neuronal properties amongst a network of receptor-mediated systems. RNA-Seq studies are poised to reveal novel transcriptome dynamics for a variety of diseases and phenotypes; however, independent studies from other model systems may extend RNA-Seq findings as additional tools and resources become available over time. RNA-Seq studies are restricted to the materials available for transcriptome profiling. Limited access to human brain tissue for alcohol dependence, as well as other neuropsychiatric conditions, often precludes investigation of temporal transcriptome changes in response to repeated substance abuse or environmental differences. Characterizing the transcriptome of postmortem brain tissue represents an end-stage molecular phenotype, the cumulative effects on the transcriptome within an individual. Expanding RNA-Seq efforts across a greater cross section of individuals and brain regions may strengthen our understanding of molecular networks influencing alcohol-drinking behavior, but across this representative sample of alcoholics emphasizes a broader picture of transcriptome differences within PFC that are related to disease. Transcriptome signatures defined by GMs in Group1 for lifetime alcohol consumption contain targets for several pharmaceutical agents that have the potential to
