Chunk #13 — Materials and Methods — 1000 Genomes imputation

Source

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

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For deCODE, genotype imputation was conducted by long-range phasing of all chip-genotyped individuals with methods described previously.29 Sequence variants were imputed from the deCODE whole-genome sequencing effort into 104 220 chip-genotyped Icelanders, who had been phased with long-range phasing, using the same model as used by IMPUTE.28