We performed logistic regression analyses to estimate the association of neuroticism with MDD and comorbid disorders (dysthymia, generalized anxiety disorder, panic disorder, agoraphobia,social phobia, animal phobia, situational phobia, and blood-injury phobia).MDD and comorbid disorders were coded as binary (1 = present, 0 = absent). Analyses of the relationship between neuroticism and the risk for lifetime MDD and comorbid disorders were conducted by binary logistic regression using SPSS version 17.0. Neuroticism scores were standardized so that the odds ratio (OR) reflected the alteration in the risk of MDD with every increase of 1 SD in neuroticism.