Furthermore, although differences in topography with age are not universally supported, Mullis et al. (1985) suggested that late adolescence to early adulthood is associated with a visual P300 amplitude shift from posterior to anterior sites in a nonpsychiatric sample. The present study and the studies by Hill and colleagues (Hill et al., 1999; Hill & Shen, 2002) that support a decreasing difference between high-and low-risk children into adulthood focused exclusively on posterior sites. Future work looking longitudinally at shifts in the contribution of different neural generators in high-and low-risk participants is needed to clarify this issue.
