Importantly, guanfacine prevented increased reinstatement in the SDPS‐prone subpopulation, and between‐group differences were no longer observed, F GROUP(2, 32) = 2.07, P = 0.142 (Figure 5C). Taken together, relapse data pointed to an SDPS‐induced facilitation of reinstatement of alcohol seeking, as shown previously.20 Importantly, this effect was selectively seen in the SDPS‐prone individuals, whereas SDPS‐resilience seemed to protect from an increase in relapse.
