Chunk #65 — Methods — Bias adjustment

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Adjustment for index event bias in genome-wide association studies of subsequent events.

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yes

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Our most serious assumption is that residuals and predictor are uncorrelated in the regression: that is there is no correlation between a SNP’s effect on incidence βGX and its direct effect on prognosis βGY. We discuss this assumption in the Results and Discussion and explore robustness to it in simulations.