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Chunk #5 — GENERATION OF SUBDOMAIN-SPECIFIC FOREBRAIN SPHEROIDS

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Assembly of functionally integrated human forebrain spheroids.
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In contrast, hSS included a cluster of ventral neural progenitors, a group of GABAergic cells expressing DLX1, GAD1, SLC32A1, SCG2, SST, and a small group of oligodendrocyte progenitors (OLIG2, SOX10) (Supplementary Table 3; Extended Data Fig. 2e–m). Astroglia from both hCS and hSS clustered together and close to a small group of cells that resemble the choroid plexus (TTR+, SLC13A4+). No cells with mesodermal or endodermal identity were found.