One hundred fifty-nine HIV-1 seropositive patients, aged 25–55 years, were recruited via advertisements posted within outpatient Infectious Disease Clinics in the greater Hartford, Connecticut, region. Interested individuals were invited to telephone a member of the research staff for eligibility screening. The telephone interview included questions about demographic characteristics, general medical status, substance use, and psychiatric symptoms. Individuals who passed the initial telephone screen were invited to visit the Health Center on a subsequent day, during which an IRB-approved consent form and a medical records release were signed. Additional eligibility screening and laboratory evaluations were performed on that day.