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Chunk #2 — Introduction

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GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
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levels than chromosome 5q34 genes. However, during development, chr4p12 genes are down regulated while chromosome 5q34 genes are up regulated (Fillman et al., 2010). Similarly, in rhesus monkeys, there is a developmental up regulation of the α1 subunit and a down regulation of the α2 subunit in the dorsolateral prefrontal cortex, which coincide with decreases in the decay time of miniature inhibitory post-synaptic potentials (Hashimoto et al., 2009).