(12 bins per disorder plus one additional bin for genome-wide significant loci for both SCZ and BIP). After scoring, the significance and magnitude of polygenic PTSD prediction was calculated for each of the 38 P-value bins. Two logistic regressions were run. The first regressed PTSD on polygenic risk score, 10 PCs and study indicator covariates. The second regression was the same as the first, but with the polygenic risk score term removed. Nagelkerke’s r2 was calculated for both models, and the difference was the r2 for the polygenic risk score term.
