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Chunk #43 — 3. Impact of spatial scale on CSD implementations — 3.3. Empirical considerations for planar (two-dimensional) scalp-recorded EEG

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Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.
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et al. (1997) noted a relationship between deblurring methods, including CSD and cortical mapping, and the inverse problem. Another application of this approach has been proposed by Yao (2001) to yield an estimate for reference-free field potentials termed reference electrode standardization technique (REST). Yao’s REST approach posits a radial dipole layer below the skull that is only used indirectly as a means to compute a theoretical reference at a point of infinity, although simpler alternatives may yield similar solutions (Ferree, 2006; Kayser and Tenke, 2010; Thuraisingham, 2011). These approaches provide advantages over standard reference schemes when a field potential topography is desired, or when there is concern over the loss of volume integration constants that occurs when the Laplacian is computed (Qin et al., 2010; Yao et al., 2005, 2007).