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Chunk #19 — Materials and Method — Genotyping

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Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.
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(versus rare variants), especially in the present sample given the relatively longer LD blocks that make the Finnish population more homogenous than other populations of mixed European ancestry. We also note that in supplementary analyses of the first 10 ancestry principal components and the ADsx and frequency of intoxication measures, we found no substantial evidence of population stratification. Out of 20 possible associations, only a single PC had a p-value of less than 0.10 (PC3 for ADsx, p = 0.04). These converging pieces of evidence suggested that it was not necessary to correct for population stratification, and informed our decision to not include ancestry principal components in our analyses.