This study shows that ethanol exposure induces many changes in LCLs, including a robust immune response seen strongly after 24 h exposure, but decreased in intensity, possibly due to a reversal of interferon signaling, after 48 h exposure. Some expression differences between the LCL from AD and controls are likely genetic, since those groups differ in genetic risk for AD. Accessible tissues like LCLs can be useful in interpreting GWAS results, and giving additional support to prioritize genes that don’t quite reach genome wide significance for follow-up studies.
