no difference in ancestry proportion as a function of diagnostic group. Similarly, although the age and sex distributions differed by diagnostic group, these differences were not correlated with genotype for the seven SNPs examined. Thus, these potential confounders did not appear to influence the findings. Based on these findings, the association of variation in GRIK1 to AD reported here warrants further research, including replication studies in EA and other populations, examination of the functional effects of the observed variation, and consideration of a potential pharmacogenetic effect of this variation in AD subjects.
