Through this retrospective nationwide study, we found that women with bipolar disorder have a greater risk and comorbidity with autoimmune and inflammatory disorders than men. Medical and psychiatric comorbidities can substantially add to impairment in function if not treated. These psychiatric comorbidities include anxiety disorders, PTSD, eating disorders and personality disorders. PTSD was the most common psychiatric co-morbidity in bipolar patients. These added comorbidities can substantially increase the disease burden of patients with bipolar disorder. Women with bipolar disorder are at an even more increased risk than men and integrating care among primary care physicians and psychiatrists closely can greatly improve the health-related quality of life and vastly decrease the burden of illness and complications. This can be attained by closer and more frequent checks and follow-ups for medical comorbidities for female patients with bipolar disorder, along with aggressive control of the physical comorbidities. During the follow-up visits, the patients should be educated by providing clear, written instructions regarding health education and directions. Frequent bipolar psychiatric comorbidities like PTSD and substance use or alcohol use disorders are either undetected or
