Chunk #36 — 4. Selectively bred high alcohol-consuming rat lines and their phenotypic characteristics — 4.4. Sardinian alcohol-preferring and alcohol-nonpreferring rats

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

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differences in the HPA-system as well. Finally, higher basal mRNA levels of the stress-responsive, arginine vasopressin (AVP) gene have been observed in the medial and central amygdala as well as the medial hypothalamus of alcohol-naive sP vs. sNP rats (Zhou et al., 2011). Overall it appears that alterations in the 5-HT, DA, GABA, opioid, cannabinoid, and AVP systems may underlie the different ethanol drinking phenotypes displayed by sP vs. sNP lines.