Several known functional variants were identified through this method, including: rs16969968(56), a nonsynonymous variant in nicotinic receptor gene CHRNA5 associated with CigDay (PPA=.92 and .84 from the fine mapping analysis with, and without, functional priors, respectively); rs1229984(57), a nonsynonymous variant in alcohol metabolism gene ADH1B associated with DrnkWk (PPA=1.0 and 1.0); and, although with somewhat weaker evidence, rs6265(58), a nonsynonymous variant in brain derived neurotrophic factor BDNF associated with SmkInit (MAF=.19; PPA=.83 and .32).
