Chunk #25 — METHODS — ORDINARY REGRESSION ON GENOTYPES AND ALLELIC DOSAGE — Non-additive

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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(4)yi=μ+β1xi(1)+β2xi(2)+εi, where εi ~ (0, σ2), as above. Again we evaluate the null hypothesis that there is no effect for any genotype, i.e. H0: =β1 = 0, β2 = 0 vs. H1: β1 ≠ 0 or β2 ≠ 0. We apply OLS regression and compute an F-statistic.