Here, we examine the effects of repeated restraint stress on the 2-AG metabolism specifically in the basolateral amygdala (BLA), and the synaptic correlates of stress-induced elevations in 2-AG content in this region. Our data indicate that 2-AG and its DAG precursors are increased within the basolateral subregion of the amygdala after repeated restraint stress. Furthermore, repeated restraint stress prolongs 2-AG-mediated retrograde signaling at inhibitory synapses in this region.
