Although no GWS association signals identified in the meta-analysis of the results from Phases1+2 were significantly associated with the corresponding trait in the much smaller Phase 3 dataset at p<0.05, three of the results improved or remained significant after meta-analysis that included the Phase 3 data (Table 1). The associations of rs62103177 in KCNG2 with Sympcountadj improved to p=3.6×10−10 (Figure 1). Two of the GWS SNPs (rs115368721 in APBB2, rs73411566 in PARVA) in Phase 2 were imputed and assays could not be designed to genotype them in Phase 3. LD-based proxies were used for APBB2 SNPs, but no suitable proxies (i.e., r2>0.4) were available for the PARVA SNP.
