not imply that the marker panels have insufficient coverage, for it has been estimated that up to 80% of the variation in the genome is correlated to current panels [Barrett and Cardon, 2006]. Rather, the statistical cost of obtaining all the remaining information is high in relation to what is already available, and the number of markers that give near-complete saturation could be much lower. Nevertheless, it is clear that denser chips are needed to obtain more accurate estimates of significance thresholds, and it is meanwhile prudent to treat these thresholds as no more than informal guidelines.
