We first performed three sets of simulations without model misspecification; i.e., where the causal pattern of enrichment was well modeled by the two-category (DHS/non-DHS) model. In these simulations, enrichment of the DHS region varied from 1x (i.e., no enrichment) to 5.5x (i.e., full enrichment, DHS SNPs explain 100% of heritability). All three methods gave unbiased estimates, although stratified LD score regression with the full baseline model had larger standard errors around the mean (Figure 2a).
