Genomewide significant associations were identified in COGA-AA on chromosome 13 (rs4770359, p=2.92E-08), although it was not associated in COGA-EA (Table 3). The variant was not replicated in the NIAAA-AA. There was modest LD support in this region possibly due to unusual LD pattern as shown in 1000 Genomes data using LDlink (https://ldlink.nci.nih.gov/?tab=home) (Figures S3D, S4). Unlike SRE-T, conditional analyses found that some variants demonstrated modest association (p<0.001) after adjustment of the top variant, suggesting that additional independent associations might exist in each region, consistent with the LD patterns showing in Figure S3D. There were no genomewide significant association findings in COGA-AA+EA and COGA-EA GWAS.
