Chunk #15 — Materials and methods — Data analysis

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Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.

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We performed power analysis of our association tests based on the sample size of each SD phenotype, and the type I errors determined by Bonferroni correction. The risk allele frequency was assumed be to 1% with relative risk of 2.