To highlight the accuracy of this approach, we observed that for publicly available gene perturbations for which we also perturbed the gene we were able to identify a significant association of target genes in ~75% of cases. While the remaining few did not pass our conservative significance criteria, they also showed increased enrichments consistent with their common effects. In addition, the projected effects are highly reproducible across distinct experiments originating from many groups and across multiple expression platforms. Highlighting the specificity of this approach, we note that there are many profiles for which no lincRNA had a similar effect.
