The results described above demonstrate that there is an advantage to characterizing the ERP signal in terms of its constituent TF components. P3-related delta activity, within particular time and frequency ranges, successfully differentiated those subjects with an externalizing spectrum disorder from those free of any disorder, above and beyond P3 peak amplitude’s ability to do so. P3 peak amplitude, however, while being the measure used in all the externalizing/substance use disorder studies we surveyed, may be more affected by noise and higher frequency activity than other measures (e.g. area or average amplitude). Therefore, to more comprehensively examine the relationship between externalizing, P3, and its TF components (PC3 specifically, given its unique relationship across externalizing spectrum disorders), we also performed follow-up analyses using additional time-domain measures.
