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Chunk #15 — 2. Methods — 2.4. MRI Data Acquisition

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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MRI scans were acquired at the Nathan Kline Institute using a 3.0 Tesla Siemens Tim Trio scanner (Erlangen, Germany). A continuous resting-state fMRI scan was acquired for the duration of 6.11 min in both AUD and CTL participants, who were instructed to keep their eyes closed but to stay awake and not to move. A series of T2*-weighted gradient echo single-shot echo-planar imaging (EPI) volumes with the following sequence parameters was acquired: Repetition Time (TR) = 2750 ms; Echo Time (TE) = 30 ms; flip angle = 80°; voxel size = (2.5 × 2.5 × 3.5) mm3; matrix size = 96 × 96; number of slices = 34; number of volumes = 130; Field of View (FOV) = 240 mm; and Grappa acceleration factor = 3. The sequence was carefully optimized to minimize the effects of magnetic susceptibility inhomogeneities (such as distortions and signal dropouts), as well as the effects of mechanical vibrations, which elevate Nyquist ghosting levels. In addition, a magnetization-prepared rapid gradient-echo (MPRAGE) high-resolution three-dimensional T1-weighted structural image was also collected to be used as an anatomical reference