In order to determine which SNPs might be contributing to a haplotype effect, a series of logistic regression models were conducted testing whether AD status (cases versus controls) was predicted by CRHR1 SNP, traumatic stress exposure, and their interaction (G × E). Genotypes were coded log-additively (0, 1, 2 copies of the minor allele). All models included sex as a covariate to control for the sex imbalance between cases and controls.
