The variant rs1696998, though still the most significant SNP in the ACS data, only accounts for 0.87% of the trait variance under a univariate RPM analysis. All of the secondary SNPs account for none of the variance under univariate RPM analysis of these data. As in the COGEND data, the univariate p values are consistent between the RPM and logistic regression analyses, and the interaction terms were not significant under the logistic regression analysis (although the final pair, rs16969968 and rs514743, displayed a nominal p value of 0.05 for the interaction term).
