We applied PolyLoc to the 49 complex traits from the UK Biobank (Supplementary Table 8). We ranked SNPs using N=337K unrelated British ancestry samples (steps 1–2) and re-estimated average per-SNP heritabilities in each of 59 SNP bins using S-LDSC applied to N=122K European-ancestry UK Biobank samples that were not included in the N=337K set to avoid winner’s curse (step 3). Estimates of M50% ranged widely from 28 (hair color) to 3.4K (height) to 2 million (number of children) (Figure 5, Supplementary Table 31). The median estimate of M50% across 16 genetically uncorrelated traits was 8.9K; the median estimate of M5% was 8; and the median estimate of M95% was 4.4 million (of 7.0 million total common SNPs) (Supplementary Table 31). Pigmentation traits were the least polygenic traits while number of children was the most polygenic trait, having M50% 3.7x larger than the second most polygenic of the 16 independent traits (chronotype, having M50%=553K), consistent with ref. 34. We performed 7 secondary analyses, described in the Supplementary Note and in Supplementary Tables 32–33. We note that far fewer than 2 million
