to glial expression in the brain.40 Furthermore, Singh et al.41 reported that 607F impacts negatively on neural progenitor proliferation in E16 mouse brain, correlates with aberrant wnt signalling in human lymphoblasts, and is associated with a neurodevelopmental phenotype in morpholino mutant zebrafish. R37W lies within an arginine-rich nuclear localisation motif and a partially overlapping interaction domain for PDE442 and GSK3β.41, 43 The 37W allele shows reduced nuclear DISC1 expression and altered DISC1 regulation of ATF4, a critical modulator of cAMP signalling and mediator of the stress response.44
