Since six SNPs were tested, level of significance for nominal p-values was set at 0.05/6=0.0083. One SNP in intron 2 of the CHRNA6 gene reached this conservative threshold, SNP rs892413 (p=0.0033) while two others in CHRNA6 attained suggestive significance: rs1072003 (also in intron 2) and rs2304297 in exon 6 (p= 0.015 and p= 0.012). One SNP, rs13280604, in intron 1 of CHRNB3 also reached the conservative threshold (p= 0.0053). The correlation of the individual phenotypes with the composite is given in Table 4.
