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Chunk #19 — RESULTS

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Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
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reduced ethanol intake and preference after 24 hours in the two-bottle choice test, as reported for the other time points above. The effectiveness of pioglitazone after 24 hours was weaker compared to its initial effects after 6 hours. Bezafibrate (75 mg/kg) reduced ethanol preference, but not intake, after 6 hours. As expected, no effects of bezafibrate were observed after 24 hours.