other putatively functional variants nearby (e.g.,26). Similarly, variation in the DRD4 gene may be more complex than the traditional binning methods and merit alternative coding strategies.21 Moreover population stratification of individual variants may artificially inflate or reduce the AGRS with the potential consequence of Type 1 or Type 2 errors. Additional research is indicated to determine whether these findings are supported in larger trials of both alcoholic and nonalcoholic samples. Interestingly, these replications attempts may be possible by leveraging existing bupropion trials, either via additional genotyping, or by creating an aggregate risk score using existing data.
