In state-dependency, information retrieval is most efficient when the animal is in the same state as it was during the information acquisition. State-dependency has been implicated across species (human, [1]; rodent, [2]; C. elegans, [3]) and with various states [1], [4], including those induced by drugs [5]. Drugs induce an internal state (an affect) that can act as a cue in learning process: when an animal learns a behavior while intoxicated, it later better recalls the behavior while being again intoxicated. Drug-induced state-dependency might, thus, underlie behaviors that are driven by drug-associated cues, e.g. drug-induced relapses in addicted individuals [6], [7]. However, the molecular correlates of state-dependency remain to be resolved.
