The original ARIC sample includes 15,792 participants (27% African American, 55% female). The publicly available dataset obtained from dbGaP for this study includes genotype and phenotype data for 12,771 individuals. Of this sample, 1,212 participants had a missing call rate >2% for SNPs called successfully in ≥95% of the sample and were excluded from subsequent analyses per quality control recommendations of the GENEVA ARIC Project 21. In addition, although the ARIC study design did not aim to include relatives, genomic analysis by the ARIC investigators revealed familial relationships at the level of half-siblings or closer among 1,674 participants. One member was selected at random from each of the 105 “families” to form a sample of unrelated persons. After these exclusions, the sample consisted of 10,745 participants (23% African American, 55% female, hereafter the “analysis sample”).
