if one manages to activate all neurons, the imposed synthetic pattern has to compete with an ongoing program because neuronal networks in the brain are spontaneously and perpetually active. The meaning of an artificial pattern for the same reader in the context where the native assembly pattern was originally observed or, say, during sleep therefore might be fundamentally different. Ideally, the imposed pattern should be embedded in the same mesoscopic temporal dynamic as the observed one. This may be facilitated, for example, by detecting LFP or firing patterns of neurons and use their phase or other features for proper timing of the synthetic pattern.
