duration synaptic GABAARs in GABAergic neurons. Different PCPs show specific subunit profiles and levels (Figure 4G, H). PVBCs express the largest variety (all except α2, α6, γ1) and overall highest levels of subunits, and uniquely high level of the GABAAR clustering/scaffolding protein gephyrin. In contrast, SST/CR cells express the least variety (mainly α3, β1/3, γ2/3) and lowest overall levels. SST/NOS1 cells are distinguished by predominant expression of slow kinetics α2-containing GABAARs and, surprisingly, the exceedingly rare γ1 subunit which is thought to assemble extra- or non- synaptic GABAaRs (Dixon et al., 2014). PVBCs and CHCs express the δ subunit, known to assemble extra-synaptic GABAaRs that possibly localize to presynaptic terminals.
