but potentially different functions82. SRCAP-containing complexes are required for the deposition of H2AZ in vivo83, although the role of these complexes in H2AZ incorporation during development has not been studied. H2AZ is conserved from yeast to mammals: how it functions in different organisms has been controversial, but it is essential for the development of both mice and D. melanogaster. Moreover, a recent genome-wide study by Boyer and colleagues showed that the incorporation of H2AZ during mouse ESC differentiation is essential for proper lineage commitment84. Hence, mammalian SWR1 complexes might be required for H2AZ incorporation during differentiation, a possibility that requires further exploration.
