latency to peak BrAC, limiting experimental control over how quickly alcohol exposures change (e.g., Norberg et al. 17 and Ramchandani et al. 18 ). Consequently, most research has focused on the response to alcohol on the ascending versus descending limbs. Nonetheless, interest in the effects of rate of change of BrAC, per se, has existed for some time. 19 , 20 , 21
