In summary (Fig. 8d), the impaired development of cortical neurons, interneurons, and cortical connections in schizophrenia may be instigated by reduced cortico-petal migration of the neuroblasts and immature neurons. In addition, the disruption of cortical neuronal programing in schizophrenia organoids coincided with the presence of the Ki67+ proliferating cells in the CZ, suggesting that these cells have failed to exit the cell cycle and differentiate.
