With regard to the stability of alcohol intake prior to and following deprivation, when alcohol intake prior to alcohol deprivation (mean of 5 days) was compared to alcohol intake during reaccess to alcohol on day 1, there was no effect of treatment, a significant effect of day F (1, 42) = 40.2, p<0.001, and a treatment X day interaction F (3, 42) = 3.1, p<0.05. Dunnett’s multiple comparisons against a single mean (VEH) revealed that, in the VEH-treated group, there was no change in alcohol intake on day 1 of alcohol reaccess when compared to alcohol intake prior to alcohol deprivation (Fig. 4). VAR, in doses of 0.5 and 1.0 mg/kg BW each reduced alcohol intake on day 1 of reaccess when compared to alcohol drinking prior to alcohol deprivation (p<0.05, and p<0.001, respectively) indicating a rapid onset of action of VAR (Fig. 4).
