the high risk environment, in this case, initiation of alcohol use at an early age (Gunzerath and Goldman, 2003; Heath et al., 2002; Heath and Nelson, 2002; Martin et al., 1987). Viewed another way, a GxE interaction may be interpreted as follows: individuals with genetic influences predisposing them to AD will be more likely to develop AD symptomatology if they are exposed to alcohol at an early age. A GxE interaction would therefore imply that, even in the presence of genetic vulnerability, delaying exposure to alcohol use will reduce the emergence of AD symptomatology.
