Among U.S. adults in 2012–2013, the prevalence of DSM-5 12-month cannabis use disorder was 2.54%, representing ~5,982,000 Americans, and the lifetime prevalence was 6.27%, representing ~14,757,000 Americans. Corresponding DSM-IV 12-month and lifetime rates in NESARC-III, 2.9% and 11.7% (29), showed that a substantial increase occurred since the 2001–2002NESARC, in which the 12-month and lifetime rates were 1.5% and 8.5% (29), an increase apparently driven by greater prevalence of cannabis users (29).