hand, human mesenchymal stem cells (hMSCs) undergo premature senescence in culture due to accumulated oxidative stress and/or constant DNA damage signaling (92, 93) (unpublished data). Stable expression of Wip1 in hMSCs lowers the stress response and overcomes premature senescence, which maintains the multi-differentiation potential (94). This suggests that modulation of the stress response by Wip1 expression in hMSCs is important for their stemness.
