(t41 = 2.235, p = 0.031, dz = 0.345; Fig. 3d). Fifth, after stimulation had restructured theta-gamma PAC in older adults, the strength of this coupling was now significantly predictive of individual working memory accuracy (r41 = 0.571, p < 0.01; Fig. 3e). The results suggest that it may be possible to improve working memory function for older adults by using a noninvasive manipulation of the brain that appears to re-establish the nesting of a cortical network in temporal cortex indexed by cross-frequency PAC.
