Table 1 lists the names and the map positions in centimorgans of the markers near those peaks with p-values less than 0.01 for genome scans using frailty models for linkage incorporating gender as a covariate or gender and smoking status as covariates for both ALDX1 and ALDX2. Frailty models identified the regions with evidence of linkage by the mean IBD tests, but with stronger signals, and also revealed some new regions with significant evidence of linkage. Adjusting for gender and smoking status as covariates, the strongest evidence of linkage to ALDX1 was achieved on a region on chromosome 7 (Table 1). Some evidence of linkage to ALDX2 was also found close to that region. The strongest evidence of linkage to ALDX2 was obtained on a region on chromosome 12. The same region was also found with some evidence of linkage to ALDX1. Figure 1 displays the multipoint linkage scans over chromosome 7 for ALDX1 and chromosome 12 for ALDX2, adjusting gender and smoking status as covariates.
