Ascertainment, consent, assessment, phlebotomy, diagnosis, ancestry, sample and genotypic quality control (QC), and sharing of biomaterials and data for the MGS2 control collection have been previously described in detail (Sanders et al. 2008; Sanders et al. 2010; Shi et al. 2009). Briefly, Knowledge Networks, Inc., a survey research company (KN), recruited self-identified non-Hispanic adult control subjects, 3,364 EA and 1,301 AA, from their nationwide panel of survey participants, which had been assembled by random digit dialing (772 of the AA controls were recruited through a subcontract to SSI, Survey Sampling International by internet banner ads). Institutional review board approval was obtained at NorthShore University HealthSystem. The order of procedures for control subjects was recruitment, online consent (identical hard-copy consent signed at venipuncture), online questionnaire completion, venipuncture for DNA extraction and establishment of lymphoblastoid cell lines (LCLs) at Rutgers University Cell and DNA Repository (RUCDR), and full anonymization of data and biomaterials. The questionnaire (available at nimhgenetics.org) was primarily comprised of the Composite International Diagnostic Interview – Short Form (CIDI-SF) (Kessler et al. 1998b; Kessler et al. 1998a; Wittchen 1994), modified
