Non-template analytic approach (2) “cluster then converge” also assessed the significance of the 83,202 and 75,327 SNPs that displayed nominally positive results in African-American and European-American samples, respectively. 17,849 SNPs from African American and 15,779 SNPs from European American samples provide clusters, within each sample, of at least 4 nominally positive SNPs that lie within ≤10kb of each other. 2,142 of these SNPs lie within clusters that identify the same genes in both African- and European-American samples (Tables 1, 2). The 341 genes that are identified in this way (Table S1) are never identified by chance, using this approach, in 100,000 Monte Carlo II simulation trials (p<0.00001)([36] and Materials and Methods). The genes identified using approach (2) overlap with ½ of the genes identified using approach (1) (Table 2).
