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Chunk #15 — Discussion

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A Brief Critique of the TATES Procedure.
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TATES was developed as a tool to summarize GWAS results across multiple phenotypes in order to obtain a single p-value, while also accounting for the correlations among the phenotypes (van der Sluis et al. 2013). Notable proposed strengths of the TATES method are that it does not assume that a specific genetic model underlies the multiple phenotypes, and it can identify genetic effects that are either phenotype-specific or common among multiple phenotypes.